Q: Name a major U.S. city in two words. Change the first letter of the first word and the next-to-last letter of the second word. Then rearrange all the letters to name the people who live in this city. What city is it?The difference is 18.
Edit: The letters you remove are Sc (Scandium, element 21) and you replace them with Li (Lithium, element 3). The difference is 18.
A: SAN FRANCISCO --> CALIFORNIANS